Body Composition
Understand weight loss, fat distribution and muscle composition in your clinical trials
Body composition analysis offers insights into the quality of weight loss and patient health. These powerful tools support decision-making in drug development across a broad spectrum of clinical trials (i.e. obesity, neuromuscular disorders, cancer cachexia).
It is time to look beyond weight…
Visceral fat
Ectopic fat
Muscle
Organ health
They all matter!
Beyond BMI – Body Composition imaging is the new global standard in weight loss clinical trials
We provide neck-to-knee MRI body composition metrics including visceral (VAT) and subcutaneous adipose tissue (SAT), lean tissue volume, skeletal muscle volume and index, muscle fat infiltration (MFI), and suspected brown adipose tissue (sBAT).
Muscle volume and muscle fat infiltration – critical indicators of quality weight loss and overall health
Ectopic fat – impairs organ health and is one of major factors in cardiometabolic disease development
End-to-end imaging services
Our body composition analysis and organ health image offers insights into weight loss and patient health. These powerful tools support decision-making and trial design in drug development across a broader spectrum of clinical trials.
Our offering includes MRI body composition, MRI multi-organ ectopic fat and full-body DEXA assessment, which are fully customisable to your trial needs.
MRI body composition
Skeletal muscle
Visceral adipose tissue (VAT)
Subcutaneous adipose tissue (SAT)
Suspected brown adipose tissue (sBAT)
Muscle fat infiltration (MFI)
Multi-organ ectopic fat
Pericardial fat
Epicardial fat
Liver fat PDFF
Pancreatic fat PDFF
Peri-renal fat
Renal sinus fat
DXA / DEXA
Lean mass
Fat mass
Total mass
Percentage body fat
Bone mineral density (BMD)
Our expertise – your success in clinical trials
Global presence
Our technology is present in 750+ sites worldwide
Regulatory and data privacy compliant
Seamless data integration and security
Rapid turnaround
In-house central platform
150+ Publications
Scientific Publications
Original article
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27
November 2024
Single-slice MRI for body composition assessment: repeatability, reproducibility, and observer variability
Original article
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1
August 2024
Quantitative imaging reveals steatosis and fibro-inflammation in multiple organs in people with type 2 diabetes: a real-world study
Original article
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24
May 2023
Bayesian networks and imaging-derived phenotypes highlight the role of fat deposition in COVID-19 hospitalization risk
Original article
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22
February 2023
Poor glycaemic control and ectopic fat deposition mediates the increased risk of non-alcoholic steatohepatitis in high-risk populations with type 2 diabetes: Insights from Bayesian-network modelling
Original article
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27
April 2022
Greater ectopic fat deposition and liver fibroinflammation and lower skeletal muscle mass in people with type 2 diabetes
Original article
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29
March 2021
Hepatic steatosis, rather than underlying obesity, increases risk of infection and hospitalization for COVID-19
Original article
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16
September 2020
Ethnic differences in body fat deposition and liver fat content in two UK-based cohorts
Original article
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27
February 2017
Characterisation of liver fat in the UK Biobank cohort
Original article
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5
July 2016
Ectopic and visceral fat deposition in lean and obese patients with type 2 diabetes
Original article
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8
December 2015
Evidence of a direct effect of myocardial steatosis on LV hypertrophy and diastolic dysfunction in adult and adolescent obesity
Original article
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12
November 2015
Investigating a liver fat: arterial stiffening pathway in adult and childhood obesity
Original article
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2
October 2015
Menopausal status and abdominal obesity are significant determinants of hepatic lipid metabolism in women
Poster
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10
January 2025
Weight loss-related changes in MRI-derived measures of body composition and liver health: a large-scale analysis from UK Biobank
Poster
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3
November 2024
Robust assessment of abdominal obesity using a single-slice L3 MRI method
Poster
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14
June 2024
Fast and robust assessment of abdominal obesity in individuals with a range of cardiometabolic and liver tissue characteristics – a retrospective analysis of UK Biobank data
Oral presentation
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19
February 2025
Population-scale MRI body composition assessment: robust associations between single-slice and volumetric muscle and adipose tissue in the UK Biobank
Original research publications:
- Greater ectopic fat deposition and liver fibroinflammation and lower skeletal muscle mass in people with type 2diabetes – Obesity - Waddell et al
- Single-sliceMRI for body composition assessment: repeatability, reproducibility, and observer variability – DiscoverImaging - Nowak et al
- Poor glycaemic control and ectopic fat deposition mediates the increased risk of non-alcoholic steatohepatitis in high-risk populations in type 2 diabetes: Insights from Bayesian-network modelling – Front. Endocrinol. - Waddell et al
- Bayesiannetworks and imaging-derived phenotypes highlight the role of fat deposition inCOVID-19 hospitalization risk – Front Bioinform - Waddell et al
Posters:
- Fast and robust assessment of abdominal obesity in individuals with a range of cardiometabolic and liver tissue characteristics. (2024) [poster] AmericanDiabetes Association - Nowak et al
- Quantitative multi-organ imaging stratifies individuals with obesity and diabetic retinopathy. (2024) [poster] American Diabetes Association – Diamond et al